A new application of Paal-Knorr reaction for synthesis of pyrrole by magnetic and highly efficient catalyst

The graphitic carbon nitride nanomagnetic catalyst (C3N4/Fe3O 4 and C3N4/SO3H) was prepared and characterized using various instrument methods. Iron oxide supported on graphitic carbon nitride and sulphonic acid supported on graphitic carbon nitride can act as well-organized nano-catalysts and can be easily separated from the reaction mixture using external magnetic fields. C3N4/Fe3O4 and C3N4/SO3H catalysts is nontoxic and inexpensive catalysts and have particular advantages like a facile synthesis procedure, high activity, easy separation, and reusability. It has applied as efficient catalysts in the synthesis of some of the organic compounds such as pyrrole derivatives in Paal- Knorr reaction. Pyrroles are an important class of heterocyclic compounds, whose structural motif appears in many biologically active natural products, and serve as building blocks in the total synthesis of these compounds. Pyrrole derivatives are important intermediates not only in the synthesis of drugs, pigments, and pharmaceuticals but also for the development of organic functional materials. many methodologies have been developed for the construction of the pyrrole skeleton. Among them, the Paal-Knorr synthesis remains the most useful preparative method for generating pyrroles. This strategy has also been utilized for the preparation of pyrrole libraries, both in solution and on the solid phase. In this research, we applied C3N4/Fe3O4 and C3N4/SO3H catalysts for synthesis of pyrrole derivatives. Pyrroles have been prepared via one-pot reaction from primary amine and 1,4-dicarbonyl compounds in ethanol at 60 ̊C. This method has many advantages such as clean reaction condition, easy workup, and easy separated catalyst.

کلیدواژه ها:

Graphitic carbon nitride ، C3N4/Fe3O4 ، C3N4/SO3H ، Paal- Knorr reaction ، Pyrrole