Antidiabetic and Antioxidant Properties of Sea Urchin Echinometra mathaei from the Persian Gulf

Background: The aim of the present study was to evaluate the inhibition of α-glucosidase and antioxidant properties of different tissues of sea urchin Echinometra mathaei. Methods: α-glucosidase inhibition was determined using p-Nitrophenyl-a-D-glucopyranoside as a substrate, and the antioxidant properties were evaluated by ۲,۲'-azino-bis (۳-ethylbenzothiazoline-۶-sulfonic acid) (ABTS),۱,۱-diphenyl-۲-picrylhydrazyl (DPPH), and nitric oxide radicals scavenging. Also, antioxidant potential was evaluated by the ferric reducing antioxidant power (FRAP) method. Results: Among the studied tissues, the highest α-glucosidase inhibition was revealed by the ethyl acetate extract of the shell and Aristotle’s lantern (IC۵۰ = ۳.۷ and ۴ mg/mL, respectively). Shell had the highest ABTS (IC۵۰ = ۱۸۳) and DPPH (IC۵۰ = ۲۰۸ μg/mL) radicals scavenging, respectively. And, gonad had the highest antioxidant potential by the FRAP method (۱۱۴۰ μg ASA/mg) and NO radical scavenging (۷۰.۶۸%), respectively. Conclusion: Antidiabetic potentials of the ethyl acetate extracts of sea urchin tissues suggest that these extracts can be used as antidiabetic drugs.

کلیدواژه ها:

Antidiabetic ، Antioxidant Properties Echinometra mathaei The Persian Gulf