Effects of Microchimeric Fetal Cells on Wound Healing

Background: tissue regeneration is a compound process that involved different factors such as signaling molecules, growth factors, and cell cycle regulators in wound healing. These factors excellently regulate cell division and differentiation at sites of injury. The ۳ stages of wound healing, namely inflammation, proliferation, and remodeling are finely controlled. Extensive skin wound therapy is a worldwide problem due to major morbidity. Therefore, we try to find methods that reduce the wound healing period. One of these methods is the use of microchimeric fetal cells (MFCs). The existence of small amounts of genetically heterogeneous cells in an organism is known as microchimerism and these cells may transport of fetus to the maternal system during and after pregnancy. In this research, we reviewed the molecular mechanism of this process and its effect on wound healing.Methods: Several of keywords including microchimeric fetal cells, pregnancy, wound healing and repairing tissue were searched in databases such as PubMed, Google Scholar, ScienceDirect, Web of Science, etc. from ۲۰۱۸ to ۲۰۲۲, and some information was obtained.Result: The majority of research showed that the presence of microchimeric fetal cells may help to improve more accelerate wound healing in pregnant mice or immediately after pregnancy. The molecular mechanisms of this process are as follows: ۱) Monocytes secrete Ccl۲ early in the site of skin wound ۲) Ccl۲ recruits a specific subpopulation of fetal cells to maternal wounds through Ccr۲ ۳) Ccl۲ improves wound healing in postpartum mice.Conclusion: These findings proved that the use of microchimeric fetal cells as a new way can provide an effective strategy in maternal tissue repair that can reduces period of wound healing.

کلیدواژه ها:

Microchimeric fetal cells ، Pregnancy ، Wound healing ، Tissue repairing