Li-Doped Bioactive Materials; Promising Biomaterials for skin Tissue Engineering and Wound Healing

Wound injuries require essential and appropriate wound care management to accelerate wound healing and achieve scar-less tissue regeneration. Lithium-ion is a trace element ion with significant therapeutic characteristics including antibacterial, anticancer, antiviral, and tissue regeneration effects. Li can facilitate angiogenesis, which is crucial in tissue repair, through upregulating expressions of VEGF. Moreover, lithium chloride acts as a trigger in Wnt, and WNT/β-catenin signaling activation, which is vital in controlling the size of the wounds. Also, it has been proven that lithium is highly effective in burn wound healing, in a dose-dependent manner. Also, Lithium's effectivity in healing is also investigated in diabetic ulcers and promoted wound healing in rat diabetes ulcers by inhibiting pigment epithelium-derived factor (PEDF). Furthermore, Li-ion demonstrated that has a considerable antibacterial effect against both gram-positive and gram-negative bacteria. Also, this ion has anti-inflammatory impact results from INF-γ synthesis inhibition and a significant reduction in TLR۲ and TLR۴ expressions, as well as increased expression of IL۱۰ simultaneously. Incorporating of lithium into the structure of biomaterials including hydrogels and bioceramics can be accomplished very conveniently. Subsequently, regarding the great advantages of lithium in wound healing, Li-incorporated biomaterials can create new horizons in wound healing.

کلیدواژه ها:

Lithium ، Wound Healing ، Antibacterial Activity ، WNT ، β-catenin ، Angiogenesis