Syzygium malaccense leaves methanol extract modulate some biochemical and inflammatory markers and prostate histology of testosterone-estradiol valerate induced benign prostatic hyperplasia in rats
محل انتشار: مجله گیاهان دارویی ابن سینا، دوره: 14، شماره: 3
سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 26
فایل این مقاله در 20 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_AJP-14-3_004
تاریخ نمایه سازی: 9 اردیبهشت 1403
چکیده مقاله:
Objective: The effect of Syzygium malaccense methanol leaf extract (SMLE) on some parameters of testosterone-estradiol valerate induced benign prostatic hyperplasia (BPH) in rats was assayed.Materials and Methods: Thirty male albino rats were used and they were grouped as: Control: received ۱ mL/kg olive oil (oral and subcutaneous); BPH: received subcutaneously ۹ mg/kg dihydrotestosterone (DHT)+۰.۹ mg/kg estradiol valerate (ESV) and orally ۱ ml/kg olive oil; finasteride: received ۹ mg/kg of DHT+۰.۹ mg/kg ESV (subcutaneously) and ۵ mg/kg finasteride (orally) and test groups ۱ and ۲: received ۹ mg/kg of DHT+۰.۹ mg/kg ESV (subcutaneously) and ۲۰۰ and ۴۰۰ mg/kg SMLE (orally). The duration of the treatment was ۲۸ days.Results: The BPH group had increased prostatic total proteins, oxidative stress, interleukin ۸, tumor necrosis factor-α, prostate weights, serum concentrations of prostate specific antigen, estradiol, follicle stimulating hormone, and C-reactive protein, dyslipidaemia, altered prostate histology and hormonal levels but had no significant change (p>۰.۰۵) in haematological indices relative to the control. Finasteride or S. malaccense modulated most of these parameters as corroborated by prostate histology. Acute toxicity study indicated the non-toxicity of SMLE. SMLE showed strong in vitro antioxidant activity which corroborated its in vivo antioxidant activity.Conclusion: The study showed that S. malaccense could be useful in the management of BPH.
کلیدواژه ها:
نویسندگان
Ngozi Kalu Achi
Department of Biochemistry, Michael Okpara University of Agriculture, Umudike, Umuahia, Abia State, Nigeria
Chinedum Ogbonnaya Eleazu
Department of Biochemistry, Alex Ekwueme Federal University, Ndufu-Alike, Ebonyi State, Nigeria
Chimaraoke Onyeabo
Department of Biochemistry, Michael Okpara University of Agriculture, Umudike, Umuahia, Abia State, Nigeria
Winner Kalu
Department of Biochemistry, Rhema University, Aba, Abia State, Nigeria
Kate Eleazu
Department of Biochemistry, Ebonyi State University, Ebonyi State, Abakaliki, Nigeria